Sustainability rests on the principle that the biosphere is the foundation of all human activities and our welfare depends on the health of our shared ecosystems. The path towards sustainability is possible only through a culture of sustainability that promotes the well-being of all generations, maintains healthy ecosystems, and fosters regenerative relations between natural, social, and technological systems. Nurturing a culture of sustainability requires acknowledging that mankind’s long-term plunder of natural and environmental resources has brought us to this point, and that we must develop new strategies in theory, practice, and action for engendering our well-being and shared ecosystems. Such an ambitious agenda can only be achieved through critical, holistic, and integrative thinking that draws upon—but also moves across—the insights and knowledge produced through traditional academic disciplines (such as natural sciences, social sciences, humanities, management, and engineering), transdisciplinary and emerging academic fields, and areas of specialization as well as through practices and actions.